Compound profile

Semax

Not approved
  • Other research peptides
  • Nootropic

Last reviewed October 2026

Educational only. A summary of published research, not medical advice or a recommendation. No doses are listed.

Quick take

A synthetic peptide derived from a fragment of ACTH (adrenocorticotropic hormone).

Class
Other research peptides
Status
Not approved
Evidence
Early or small human studies
Half-life
Not well documented

Mechanism fingerprint

What it acts on, and how. Each chip links to that pathway on the map.

Studied for effects on brain-derived neurotrophic factor (BDNF) and recovery after stroke.

What makes it different

Derived from a fragment of ACTH; studied for BDNF and recovery after stroke.

Compare side by side

Mechanism & pathways

Semax
  • Studied link BDNF

    Brain-derived neurotrophic factor, a protein that supports the growth and connections of nerve cells.

Dashed boxes are studied or proposed links from early research, not confirmed actions. See Semax on the pathway map

Evidence overview

Early or small human studies

Clinical studies are mostly small and published in Russia.

A breakdown into human, animal and cell studies hasn't been added for this compound yet.

Why it's used

Used for focus and memory, and in Russia for recovery after stroke.

Side effects & risks

Reported side effects

  • Not well characterized outside Russian studies

Risks and warnings

  • Not evaluated by US or EU regulators
  • Products sold as “research use only” are not quality-controlled medicines; purity, sterility and labeled amount are not verified.

FAQ

Short answers taken from this profile.

What is Semax?

A synthetic peptide derived from a fragment of ACTH (adrenocorticotropic hormone).

How does Semax work?

Studied for effects on brain-derived neurotrophic factor (BDNF) and recovery after stroke.

What receptors or pathways does Semax act on?

BDNF (studied link). Links marked “studied” or “proposed” come from early research and aren't confirmed in people.

How is Semax different from similar compounds?

Derived from a fragment of ACTH; studied for BDNF and recovery after stroke.

Is Semax approved?

Registered in Russia (nasal drops) for stroke and other neurological conditions; not approved in the US or EU.

What has Semax been studied for?

Used for focus and memory, and in Russia for recovery after stroke.

How strong is the evidence?

Early or small human studies. Clinical studies are mostly small and published in Russia.

What are the main risks?

Not evaluated by US or EU regulators. Products sold as “research use only” are not quality-controlled medicines; purity, sterility and labeled amount are not verified.