CoachP

Effect

Appetite

Changes in hunger and fullness, in either direction. Gut-hormone medicines mostly reduce appetite; a few compounds are reported to increase it.

7 compounds in the guide

Educational only. A summary of published research, not medical advice or a recommendation. No doses are listed. Compounds are listed from the strongest evidence to the weakest. Being listed isn't a recommendation.

Related pathways

The receptors and pathways behind this effect.

Compounds

  • Semaglutide

    FDA-approved

    GLP-1 & weight-loss peptides · Large human trials

    A long-acting GLP-1 receptor agonist that lowers blood sugar, slows stomach emptying and reduces appetite.

  • Tirzepatide

    FDA-approved

    GLP-1 & weight-loss peptides · Large human trials

    A once-weekly dual agonist of the GIP and GLP-1 receptors used for type 2 diabetes and weight management.

  • Retatrutide

    Investigational

    GLP-1 & weight-loss peptides · Large human trials

    An investigational once-weekly “triple agonist” that acts on the GIP, GLP-1 and glucagon receptors.

  • Survodutide

    Investigational

    GLP-1 & weight-loss peptides · Early or small human studies

    An investigational dual agonist of the glucagon and GLP-1 receptors.

  • Cagrilintide

    Investigational

    GLP-1 & weight-loss peptides · Early or small human studies

    An investigational long-acting analogue of amylin, a hormone released with insulin that helps you feel full.

  • Melanotan II

    Not approved

    Melanocortin peptides · Early or small human studies

    A synthetic analogue of α-melanocyte-stimulating hormone, sold illegally as a tanning product.

  • Boldenone

    Veterinary only

    Anabolic steroids · Mostly animal & lab studies

    A long-acting veterinary injectable related to testosterone, known among users for raising appetite and red blood cell counts.

Other effects