Effect
Glucose control
Keeping blood sugar in a healthy range. In diabetes trials it's measured as HbA1c, the average blood sugar over about three months.
4 compounds in the guide
Educational only. A summary of published research, not medical advice or a recommendation. No doses are listed. Compounds are listed from the strongest evidence to the weakest. Being listed isn't a recommendation.
Related pathways
The receptors and pathways behind this effect.
Compounds
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Semaglutide
FDA-approvedA long-acting GLP-1 receptor agonist that lowers blood sugar, slows stomach emptying and reduces appetite.
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Tirzepatide
FDA-approvedA once-weekly dual agonist of the GIP and GLP-1 receptors used for type 2 diabetes and weight management.
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Retatrutide
InvestigationalAn investigational once-weekly “triple agonist” that acts on the GIP, GLP-1 and glucagon receptors.
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MOTS-c
Not approvedA 16-amino-acid peptide encoded in mitochondrial DNA, first described in 2015.