CoachP

Effect

Fat loss

Losing body fat, usually measured as a change in body weight or fat mass. This covers medicines approved or in trials for weight loss, and compounds studied for fat breakdown.

8 compounds in the guide

Educational only. A summary of published research, not medical advice or a recommendation. No doses are listed. Compounds are listed from the strongest evidence to the weakest. Being listed isn't a recommendation.

Related pathways

The receptors and pathways behind this effect.

Compounds

  • Semaglutide

    FDA-approved

    GLP-1 & weight-loss peptides · Large human trials

    A long-acting GLP-1 receptor agonist that lowers blood sugar, slows stomach emptying and reduces appetite.

  • Tirzepatide

    FDA-approved

    GLP-1 & weight-loss peptides · Large human trials

    A once-weekly dual agonist of the GIP and GLP-1 receptors used for type 2 diabetes and weight management.

  • Retatrutide

    Investigational

    GLP-1 & weight-loss peptides · Large human trials

    An investigational once-weekly “triple agonist” that acts on the GIP, GLP-1 and glucagon receptors.

  • Tesamorelin

    FDA-approved

    Growth hormone secretagogues · Large human trials

    A synthetic analogue of growth hormone–releasing hormone (GHRH) that prompts the pituitary to release growth hormone.

  • Survodutide

    Investigational

    GLP-1 & weight-loss peptides · Early or small human studies

    An investigational dual agonist of the glucagon and GLP-1 receptors.

  • Cagrilintide

    Investigational

    GLP-1 & weight-loss peptides · Early or small human studies

    An investigational long-acting analogue of amylin, a hormone released with insulin that helps you feel full.

  • AOD-9604

    Not approved

    Other research peptides · Early or small human studies

    A modified fragment from the end of the human growth hormone molecule, originally developed as an anti-obesity drug.

  • MOTS-c

    Not approved

    Other research peptides · Mostly animal & lab studies

    A 16-amino-acid peptide encoded in mitochondrial DNA, first described in 2015.

Other effects